3 PhD Positions (m/f) / Department Experimental Diabetology
Project 1 (reference nr. 2016_W10_R):
The broad theme of this research project is the Development of strategies to prevent and treat fatty liver disease. The PhD student will perform lab-based studies in mice (phenotypic characterization) that are treated with different compounds and diets. In particular, liver samples will be studied in more detail in respect to expression patterns, epigenetic alterations (DNA methylation) and lipid profiles. Our overall objective is to enhance our knowledge on physiological changes that occur during obesity, insulin resistance and diabetes and to translate this to humans.
Project 2 (reference nr. 2016_W11_R):
The broad theme of this research project is the Molecular characterization of a novel obesity gene. The PhD student will perform lab-based tissue culture experiments and studies in transgenic mice (phenotypic characterization). In both approaches the expression of the obesity gene will be manipulated and the differentiation capacity of adipocytes as well as the metabolism will be investigated in more detail. Our overall objective is to enhance our knowledge on physiological changes that occur in the different fat depots during obesity, insulin resistance and diabetes and to translate this to human.
Project 3 (reference nr. 2016_W12_R):
The broad theme of this research project is the Investigation of pathomechanisms resulting in beta-cell loss. The PhD student will perform lab-based tissue culture experiments with beta cells. In addition, Langerhans islets will be isolated from mice for further analysis such as expression profiling, immunostaining and confocal microscopy as well as detection of insulin secretion after manipulation of specific genes. Our overall objective is to enhance our knowledge on beta cell failure and the development of type 2 Diabetes.
DESIRED SKILLS AND EXPERIENCE
The DIfE invites applicants from academic backgrounds in an appropriate discipline e.g. - biochemistry, biology, nutrition science, pharmacy from all countries.
Please send your application with the reference nr. and name of the Project until latest January, 27th 2017 via the Apply for this job button or in print to:
German Institute of Human Nutrition
Human Resources and Social Services
For further information please do not hesitate to contact:
Prof. Dr. Annette Schurmann, head of department Experimental Diabetology,
Tel.: (+49) 33200/88-2368; E-Mail: firstname.lastname@example.org
ABOUT THE EMPLOYER
The German Institute of Human Nutrition Potsdam-Rehbrucke is a member of the Leibniz association and its mission is to conduct experimental and clinical research in the field of nutrition and health.
The Department of Experimental Diabetology is an internationally recognized research-based department encompassing life sciences and a partner of the German Center for Diabetes Research (DZD).
The institute offers excellent working conditions in an interactive and multidisciplinary research environment, with state-of-the-art equipment, qualified training and enrolment in a local PhD program. The advertised positions are available for 3 years. PhD position will be paid according to the terms of the civil service collective bargaining act (TV-L 50% of level E13).